News
Lab news
Papers out, preprints posted, people arriving and moving on.
August 2026
Karthik is at the NITMB workshop on spin glass theory and high-dimensional
landscapes in biology, in Chicago.
Workshop page.
2026
Brooke's paper is accepted at Cell Reports Physical Sciences.
An information-theoretic framework for transcriptional regulation, showing that
communication fidelity declines with age. Work with Chris Lynn, Andrew Mugler, and
Fabrisia Ambrosio.
2026
Jeremy's paper is accepted at Physical Review Research.
Endocytosis shapes the extracellular chemical gradients cells use to attract each other,
so a cell sharpens a signal by consuming it.
2026
Karthik's paper is accepted at PRX Life. Coexistence in complex
microbial ecosystems turns out to be low-dimensional.
May 2026
New preprint with the Urtecho lab on
metagenome-scale modeling of metabolic
complementarity, aimed at making microbiota transplantation more predictable.
December 2025
Andrew's directional sensing paper is published in PNAS. Receptor
degradation combined with diffusion turns out to be sufficient for a eukaryotic cell to
read a shallow gradient.
Read it.
October 2025
Brooke posts her first preprint. Transcriptional information flow decays
as cells age, work done with Chris Lynn, Andrew Mugler, and Fabrisia Ambrosio.
bioRxiv.
October 2025
Ligand specificity paper out in eLife, on the non-equilibrium strategies
receptors use to distinguish ligands that bind almost identically.
Read it.
May 2025
Minimax entropy, with the Lynn lab, appears in Physical Review E. What makes one
statistical model better than another that fits the data equally well?
January 2025
Karthik's microbiome design paper is published in mSystems. Consumer/resource
models give a way to reason about which communities will actually persist in a host.
Read it.
August 2024
Work with Genentech on dosing panRAF and MEK inhibitors in melanoma is published in
Cancers, out of Andrew's 2023 internship.
May 2024
A global view of T cell metabolism in lupus, with the Morel and Brusko labs, is out in
Frontiers in Immunology.
January 2024
The sensing heterogeneity paper is published in eLife. The ability to
sense the environment is distributed very unevenly across a cell population.
Read it.
November 2023
Hoda defended her PhD, the first from the lab, and GENERALIST was
accepted at PLoS Computational Biology.
July 2023
The lab moves to Yale, joining the Department of Biomedical Engineering.
June 2023
EMBED is published in npj Systems Biology and Applications.
August 2021
The lab is awarded a MIRA (R35) from NIGMS for MANET, maximum entropy neural networks for
mechanistic modeling of single cell behavior.